Provided is a saddle-ride type vehicle, which does not reduce cooling efficiency of an engine, is hardly affected by heat from the engine, and can increase a degree of freedom of configuration such as the orientation at the time of arrangement, size and shape of a shift actuator. The saddle-ride type vehicle (100) includes the engine (120), and the engine (120) has a cylinder block (120a), a cylinder head (120b) and a head cover (120c) and has a crankcase (123) below the cylinder block (120a). The saddle-ride type vehicle (100) also includes a shift drum drive unit (140) for rotating a shift drum (136) which changes a gear train (133) in a transmission (132). The shift drum drive unit (140) includes a shift actuator (141) formed of an electric motor, and a decelerator (142). The shift drum drive unit (140) is attached to a front surface of the crankcase (123) below the cylinder block (120a) via a unit case (146) housing the decelerator (142).