Multi-target post-copy guest migration is disclosed. For example, first, second, and third host nodes are associated with respective first, second, and third memories and respective first, second, and third isolated guest managers. An isolated guest, previously migrated from the first host node, executes on the second host node with a first memory page in the first memory and second and third memory pages in the second memory. The isolated guest is requested to migrate to the third host node. The isolated guest executes on the third host node after the third memory page is migrated. The isolated guest requests the first memory page. The third memory is determined to lack the first memory page, and in response, the first and second isolated guest managers are notified that the first memory page is required by the third host resulting in the first memory page being sent to the third host.