A system and a method of clock-gating for multicycle instructions are provided. For example, the method includes enabling a plurality of logic blocks that include a subset of multicycle (MC) logic blocks and a subset of pipeline logic blocks. The method also includes computing a precise enable computation value after a plurality of cycles of executing an instruction, and disabling one or more of the subset of multicycle (MC) logic blocks based on the precise enable computation value. Also, at least the subset of pipeline logic blocks needed to compute the instruction remains on.