Embodiments of the present invention relate to providing fault-tolerant power minimization in a multi-core neurosynaptic network. In one embodiment of the present invention, a method of and computer program product for fault-tolerant power-driven synthesis is provided. Power consumption of a neurosynaptic network is modeled as wire length. The neurosynaptic network comprises a plurality of neurosynaptic cores connected by a plurality of routers. At least one faulty core of the plurality of neurosynaptic cores is located. A placement blockage is modeled at the location of the at least one faulty core. A placement of the neurosynaptic cores is determined by minimizing the wire length.