A present technology relates to a transmission device, a transmission method, a reception device, a reception method, and a program that can improve reception performance of a frame to which a preamble is added. A transmission device of one aspect of the present technology generates a preamble including a sequence [d d . . . d −d] having iteration of a sequence d that is one of sequences a and b that are Golay complementary sequences, followed by an inverted sequence of the sequence d, and including a signal sequence in which a maximum value of an absolute value of a side lobe level of cross correlation between a sequence [d d −d] and a sequence [d −d] is 25 or less. The generated preamble is added to data to be transmitted in units of frames. The present technology can be applied to a device that transmits and receives data via a wireless transmission path.