Embodiments of hybrid network processing load distribution in a computing device are disclosed therein. In one embodiment, a method includes receiving, at a main processor, an indication from the network interface controller to perform network processing operations for first and second packets in a queue of a virtual port of the network interface controller, and in response to receiving the request, assigning first and second cores for performing the network processing operations for the first and second packets, respectively. The method also includes performing the network processing operations at the first and second cores to effect processing and transmission of the first and second packets to first and second applications, respectively, both the first and second applications executing in a virtual machine hosted on the computing device.