Invention Grant
- Patent Title: 2-amino-N′-benzylideneacetohydrazides and derivatives for the management of CFTR protein mediated diseases
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Application No.: US15578100Application Date: 2016-05-27
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Publication No.: US10555918B2Publication Date: 2020-02-11
- Inventor: Nael McCarty , Guiying Cui , Hanoch Senderowitz , Netaly Khazanov
- Applicant: Emory University , Bar-Ilan University , Children's Healthcare of Atlanta, Inc.
- Applicant Address: US GA Atlanta IL Ramat Gan US GA Atlanta
- Assignee: Emory University,Bar-Ilan University,Childern's Healthccare of Atlanta, Inc.
- Current Assignee: Emory University,Bar-Ilan University,Childern's Healthccare of Atlanta, Inc.
- Current Assignee Address: US GA Atlanta IL Ramat Gan US GA Atlanta
- Agency: Emory Patent Group
- International Application: PCT/US2016/034662 WO 20160527
- International Announcement: WO2016/196297 WO 20161208
- Main IPC: A61K31/16
- IPC: A61K31/16 ; A61K31/443 ; C07C251/86 ; A61K31/47 ; A61P11/12
Abstract:
This disclosure relates to methods of treating or preventing cystic fibrosis transmembrane conductance regulator (CFTR) mediated diseases such as cystic fibrosis, chronic obstructive pulmonary disease, chronic pancreatitis, chronic bronchitis, asthma, mucus formation, comprising administering an effective amount of a 2-amino-N′-benzylidene-acetohydrazide compound or derivative thereof to a subject in need thereof. In certain embodiments, the 2-amino-N′-benzylidene-acetohydrazide compound is ((E)-N′-(3,5-dibromo-2,4-dihydroxybenzylidene)-2-(m-tolylamino)acetohydrazide; or (E)-N′-(3,5-dibromo-2,4-dihydroxybenzylidene)-2-(p-tolylamino)acetohydrazide.
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