Invention Grant
- Patent Title: Difluorolactam compounds as EP4 receptor-selective agonists for use in the treatment of EP4-mediated diseases and conditions
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Application No.: US16155400Application Date: 2018-10-09
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Publication No.: US10556862B2Publication Date: 2020-02-11
- Inventor: Stephen Douglas Barrett , Fred Lawrence Ciske , Joseph Michael Colombo , Gregory William Endres , Bradlee David Germain , Andriy Komilov , James Bernard Kramer , Adam Uzieblo , Kirk M. Maxey
- Applicant: Cayman Chemical Company, Inc.
- Applicant Address: US MI Ann Arbor
- Assignee: CAYMAN CHEMICAL COMPANY, INC.
- Current Assignee: CAYMAN CHEMICAL COMPANY, INC.
- Current Assignee Address: US MI Ann Arbor
- Agency: Barnes & Thornburg
- Main IPC: A61K31/4015
- IPC: A61K31/4015 ; A61K31/4025 ; C07D207/26 ; C07D409/06 ; C07D207/273 ; A61L24/00 ; A61L24/02 ; A61L27/12 ; A61L27/36 ; A61L27/54 ; A61L27/58
Abstract:
Disclosed herein are compounds of formula (I) and therapeutic methods of treatment with compounds of formula (I), wherein L1, L2, L4, R1, R4, R5, R6, and s are as defined in the specification. Compounds of formula (I) are EP4 agonists useful in the treatment of glaucoma, neuropathic pain, and related disorders.
Public/Granted literature
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