Invention Grant
- Patent Title: ROR gamma (RORγ) modulators
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Application No.: US15579164Application Date: 2016-06-03
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Publication No.: US10556866B2Publication Date: 2020-02-11
- Inventor: Joseph Maria Gerardus Barbara Cals , Sander Bernardus Nabuurs
- Applicant: LEAD PHARMA HOLDING B.V. , SANOFI
- Applicant Address: NL Nijmegen FR Paris
- Assignee: LEAD PHARMA HOLDING B.V.,SANOFI
- Current Assignee: LEAD PHARMA HOLDING B.V.,SANOFI
- Current Assignee Address: NL Nijmegen FR Paris
- Agency: Morrison & Foerster LLP
- Priority: EP15170765 20150605
- International Application: PCT/EP2016/062701 WO 20160603
- International Announcement: WO2016/193461 WO 20161208
- Main IPC: C07C317/32
- IPC: C07C317/32 ; C07D213/81 ; C07C311/46 ; A61P37/00 ; A61P29/00

Abstract:
Novel compounds according to Formula I or a pharmaceutically acceptable salt thereof wherein: A11-A14 are N or CR11, CR12, CR13, CR14, respectively, with the proviso that no more than two of the four positions A can be simultaneously N; R1 is C(2-6)alkyl, C(3-6)cycloalkyl, C(3-6)cycloalkylC(1-3)alkyl, (di)C(3-6)cycloalkylamino or (di)(C(3-6)cycloalkylC(1-3)alkyl)amino; R5 is H, hydroxyethyl, methoxyethyl, C(1-6)alkyl, C(6-10)aryl, C(6-10)arylC(1-3)alkyl, C(1-9)heteroaryl, C(1-9)heteroarylC(1-3)alkyl, C(3-6)cycloalkyl, (3-6)cycloalkylC(1-3)alkyl, C(2-5)heterocycloalkyl or C(2-5)heterocycloalkyl-C(1-3)alkyl; the sulfonyl group with R1 is represented by one of R7, R8 or R9; R15 is H, C(1-6)alkyl, C(3-6)cycloalkyl, C(3-6)cycloalkylC(1-3)alkyl, C(6-10)aryl, C(6-10)arylC(1-3)alkyl, C(1-9)heteroaryl, C(1-9)heteroarylC(1-3)alkyl, C(2-5)heterocycloalkyl or C(2-5)heterocycloalkylC(1-3)alkyl; and R16 is C(1-6)alkyl, C(3-6)cycloalkyl, C(3-6)cycloalkylC(1-3)alkyl, C(6-10)aryl, C(6-10)arylC(1-3)alkyl, C(1-9)heteroaryl, C(1-9)heteroarylC(1-3)alkyl, C(2-5)heterocycloalkyl or C(2-5)heterocycloalkylC(1-3)alkyl. The compounds can be used as inhibitors of RORγ and are useful for the treatment of RORγ mediated diseases.
Public/Granted literature
- US20180162815A1 ROR GAMMA (RORY) MODULATORS Public/Granted day:2018-06-14
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