Invention Grant
- Patent Title: Process for the production of condensed imidazolo derivatives
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Application No.: US15546707Application Date: 2016-01-28
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Publication No.: US10556869B2Publication Date: 2020-02-11
- Inventor: Andreas Bertogg , Hanspeter Schilling
- Applicant: Novartis AG
- Applicant Address: CH Basel
- Assignee: Novartis AG
- Current Assignee: Novartis AG
- Current Assignee Address: CH Basel
- Agent Michelle Han
- International Application: PCT/IB2016/050433 WO 20160128
- International Announcement: WO2016/120821 WO 20160804
- Main IPC: C07D487/00
- IPC: C07D487/00 ; C07D233/54 ; A61K31/4184 ; C07D403/10 ; C07D487/04 ; C07D471/04 ; C07D473/00

Abstract:
The present invention relates to a process for providing the compound of formula I, comprising the step of reacting a compound of formula VII with a base in the presence of an alkaline- or alkaline earth metal salt (MX), wherein LG is a leaving group. The presence of an alkaline- or alkaline earth metal salt was surprisingly found to render said reaction highly reliable in terms of the yield and purity of the compound of formula I obtained. In a further aspect, the present invention relates to the compound of formula I, having less than an amount of 1.50% or less than an amount of 1.25% or less than an amount of 1.00% or less than an amount of 0.75% or less than an amount of 0.50% or less than an amount of 0.25% or less than an amount of 0.10% of the compound of formula VIII.
Public/Granted literature
- US20180002292A1 PROCESS FOR THE PRODUCTION OF CONDENSED IMIDAZOLO DERIVATIVES Public/Granted day:2018-01-04
Information query