Invention Grant
- Patent Title: Method for preparing Maraviroc
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Application No.: US16257987Application Date: 2019-01-25
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Publication No.: US10556899B2Publication Date: 2020-02-11
- Inventor: Heng-Yen Wang , Chen-Yi Kao
- Applicant: SCI Pharmtech, Inc.
- Applicant Address: TW Taoyuan
- Assignee: SCI Pharmtech, Inc.
- Current Assignee: SCI Pharmtech, Inc.
- Current Assignee Address: TW Taoyuan
- Agency: Mintz Levin Cohn Ferris Glovsky and Popeo, P.C.
- Agent Peter F. Corless; Joohee Lee
- Main IPC: C07D451/02
- IPC: C07D451/02

Abstract:
Provided is a method for preparing a tropane derivative, maraviroc, including reacting a compound of formula (II) with a compound of formula (I), wherein the compound of formula (II) is prepared by the steps of acetylation of a compound of formula (III), activation and substitution of a compound of formula (IV) by a chlorination agent, cyclization of a compound of formula (V), and debenzylation of a compound of formula (VI) by hydrogenation. Hence, the present disclosure provides a method for preparing maraviroc with good yield and simple operation.
Public/Granted literature
- US20190248782A1 METHOD FOR PREPARING MARAVIROC Public/Granted day:2019-08-15
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