Invention Grant
- Patent Title: TrkA kinase inhibitors, compositions and methods thereof
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Application No.: US15562617Application Date: 2016-04-04
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Publication No.: US10556900B2Publication Date: 2020-02-11
- Inventor: Craig A. Stump , Yi Heng Chen , Ping Liu , Dongfang Meng , Jane Yang Wu , Chun Sing Li , Zhiqi Qi
- Applicant: Merck Sharp & Dohme Corp.
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agent Dianne Pecoraro; John C. Todaro
- Priority: CNPCT/CN2015/076042 20150408
- International Application: PCT/US2016/025810 WO 20160404
- International Announcement: WO2016/164286 WO 20161013
- Main IPC: C07D471/04
- IPC: C07D471/04 ; C07D487/04 ; C07D403/12 ; C07D417/12 ; A61P7/02 ; A61P17/06 ; A61P9/10 ; A61P25/00 ; A61P35/00
Abstract:
The present invention is directed to bicyclic heteroaryl benzamide compounds of formulas (I): which are tropomyos-in-related kinase (Trk) family protein kinase inhibitors, and hence are useful in the treatment of pain, inflammation, cancer, restenosis, atherosclerosis, psoriasis, thrombosis, a disease, disorder, injury, or malfunction relating to dysmyelination or demyelination or a disease or disorder associated with abnormal activities of nerve growth factor (NGF) receptor TrkA.
Public/Granted literature
- US20180105518A1 TRKA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF Public/Granted day:2018-04-19
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