Invention Grant
- Patent Title: Broad spectrum conjugate vaccine to prevent klebsiella pneumoniae and pseudomonas aeruginosa infections
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Application No.: US15842068Application Date: 2017-12-14
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Publication No.: US10556931B2Publication Date: 2020-02-11
- Inventor: Raphael Simon , Alan Cross , Sharon Tennant
- Applicant: Raphael Simon , Alan Cross , Sharon Tennant
- Applicant Address: US MD Baltimore
- Assignee: UNIVERSITY OF MARYLAND, BALTIMORE
- Current Assignee: UNIVERSITY OF MARYLAND, BALTIMORE
- Current Assignee Address: US MD Baltimore
- Agency: Nevrivy Patent Law Group P.L.L.C.
- Main IPC: A61K39/02
- IPC: A61K39/02 ; C07K14/21 ; A61K39/104 ; C07K14/26 ; A61K39/108 ; A61K47/64 ; A61K39/00 ; A61K47/61

Abstract:
The present invention is drawn to conjugates and vaccine compositions comprising a Pseudomonas flagellin or an antigenic fragment or derivative thereof linked to one or more Klebsiella surface polysaccharide antigens, such as Klebsiella pneumoniae O polysaccharide from serovars O1, O2a, O2a,c, O3, O4, O5, O7, O8 and O12. The present invention also provides serovar reagent strains to produce the conjugates and vaccine compositions and methods of inducing an immune response with the conjugates and vaccine compositions.
Public/Granted literature
- US20180194812A1 BROAD SPECTRUM CONJUGATE VACCINE TO PREVENT KLEBSIELLA PNEUMONIAE AND PSEUDOMONAS AERUGINOSA INFECTIONS Public/Granted day:2018-07-12
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