Invention Grant
- Patent Title: T cell receptors recognizing HLA-Cw8 restricted mutated KRAS
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Application No.: US15758954Application Date: 2016-09-09
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Publication No.: US10556940B2Publication Date: 2020-02-11
- Inventor: Eric Tran , Yong-Chen Lu , Steven A. Rosenberg
- Applicant: The United States of America, as represented by the Secretary, Department of Health and Human Services
- Applicant Address: US MD Bethesda
- Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
- Current Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
- Current Assignee Address: US MD Bethesda
- Agency: Leydig, Voit & Mayer
- International Application: PCT/US2016/050875 WO 20160909
- International Announcement: WO2017/048593 WO 20170323
- Main IPC: C07K14/725
- IPC: C07K14/725 ; G01N33/574 ; A61K38/00
Abstract:
Disclosed is an isolated or purified T cell receptor (TCR) having antigenic specificity for mutated Kirsten rat sarcoma viral oncogene homolog (KRAS) presented in the context of an HLA-Cw*0802 molecule. Related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions are also provided. Also disclosed are methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal.
Public/Granted literature
- US20190040111A1 T CELL RECEPTORS RECOGNIZING HLA-CW8 RESTRICTED MUTATED KRAS Public/Granted day:2019-02-07
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