Invention Grant
- Patent Title: Method for chondrogenic induction
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Application No.: US15552156Application Date: 2016-02-19
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Publication No.: US10557121B2Publication Date: 2020-02-11
- Inventor: Noriyuki Tsumaki
- Applicant: Kyoto University
- Applicant Address: JP Kyoto
- Assignee: Kyoto University
- Current Assignee: Kyoto University
- Current Assignee Address: JP Kyoto
- Agency: Knobbe Martens Olson & Bear LLP
- Priority: JP2015-030168 20150219
- International Application: PCT/JP2016/054917 WO 20160219
- International Announcement: WO2016/133208 WO 20160825
- Main IPC: C12N5/00
- IPC: C12N5/00 ; C12N5/02 ; C12N5/077 ; A61P19/04 ; A61K35/35 ; A61L27/38 ; A61L27/54

Abstract:
Provided is a method for producing chondrocytes from pluripotent stem cells, the method comprising the steps of: (i) culturing pluripotent stem cells under adherent conditions in a medium containing an HMG-CoA reductase inhibitor and one or more substances selected from the group consisting of BMP2, TGFβ and GDF5, and (ii) culturing the cells obtained in step (i) under suspension conditions in a medium containing an HMG-CoA reductase inhibitor and one or more substances selected from the group consisting of BMP2, TGFβ and GDF5. Also provided is a pharmaceutical product comprising chondrocytes obtained by the method.
Public/Granted literature
- US20180251732A1 NOVEL METHOD FOR CHONDROGENIC INDUCTION Public/Granted day:2018-09-06
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