Invention Grant
- Patent Title: Modulating apolipoprotein (a) expression
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Application No.: US15772649Application Date: 2016-11-07
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Publication No.: US10557137B2Publication Date: 2020-02-11
- Inventor: Nicholas J. Viney , Richard S. Geary , Yanfeng Wang , Zhengrong Yu
- Applicant: Ionis Pharmaceuticals, Inc.
- Applicant Address: US CA Carlsbad
- Assignee: Ionis Pharmaceuticals, Inc.
- Current Assignee: Ionis Pharmaceuticals, Inc.
- Current Assignee Address: US CA Carlsbad
- Agency: Grant IP, Inc.
- International Application: PCT/US2016/060816 WO 20161107
- International Announcement: WO2017/079739 WO 20170511
- Main IPC: C12N15/113
- IPC: C12N15/113 ; A61K9/08 ; A61J1/05 ; A61K9/00

Abstract:
Provided herein are oligomeric compounds with conjugate groups targeting apoplipoprotein (a) [apo(a)]. In certain embodiments, the apo(a) targeting oligomeric compounds are conjugated to N-Acetylgalactosamine. Also disclosed herein are conjugated oligomeric compounds targeting apo(a) for use in decreasing apo(a) to treat, prevent, or ameliorate diseases, disorders or conditions related to apo(a) and/or Lp(a). Certain diseases, disorders or conditions related to apo(a) and/or Lp(a) include inflammatory, cardiovascular and/or metabolic diseases, disorders or conditions. The conjugated oligomeric compounds disclosed herein can be used to treat such diseases, disorders or conditions in an individual in need thereof.
Public/Granted literature
- US20190136233A1 MODULATING APOLIPOPROTEIN (A) EXPRESSION Public/Granted day:2019-05-09
Information query
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