Invention Grant
- Patent Title: Yeast host cells and methods for producing fatty alcohols
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Application No.: US15979144Application Date: 2018-05-14
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Publication No.: US10557152B2Publication Date: 2020-02-11
- Inventor: Leopold D'Espaux , Jay D. Keasling
- Applicant: Leopold D'Espaux , Jay D. Keasling
- Applicant Address: US CA Oakland
- Assignee: The Regents of the University of California
- Current Assignee: The Regents of the University of California
- Current Assignee Address: US CA Oakland
- Agency: Lawrence Berkeley National Laboratory
- Agent Robin C. Chiang
- Main IPC: C12P7/04
- IPC: C12P7/04 ; C12N9/02 ; C12N9/10 ; C12N9/00 ; C12N15/52
Abstract:
The present invention provides for a genetically modified yeast cell comprising at least six or more of the following modifications: increased expression of Mus musculus fatty acid reductase, acetyl-CoA carboxylase, fatty acid synthase 1, fatty acid synthase 2, a mutant of the bottleneck enzyme encoded by ACC1 insensitive to post-transcriptional and post-translational repression, and/or a desaturase encoded by OLE1, and reduced expression of DGA1, HFD1, ADH6, and/or GDH1. The present invention provides a method for constructing the genetically modified yeast cell, and a method for producing a fatty alcohol from the genetically modified yeast cell.
Public/Granted literature
- US20190136266A1 Yeast Host Cells and Methods for Producing Fatty Alcohols Public/Granted day:2019-05-09
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