A touch control substrate, a driving method thereof, a display panel and a display device are provided. The touch control substrate includes: a base substrate; a plurality of touch electrode blocks, disposed on the base substrate and arranged in an array; a resistance detection module, used for inputting a driving signal to the touch electrode blocks; a first control module, used for determining which touch electrode block is touched according to a time at which the touch electrode blocks in each row output the driving signal; a capacitance detection module, used for inputting a capacitance detection signal to sub-electrodes in each of two sub-rows of a row where the touched touch electrode block is located; and a second control module, used for determining a position of a touch point according to a capacitance feedback signal output by two sub-electrodes corresponding to the touched touch electrode block.