Embodiments of the present disclosure support hardware based thread switching in a multithreading environment. The thread switching is implemented on a multithread microprocessor by utilizing thread mailbox registers and other auxiliary registers that can be pre-programmed for hardware based thread switching. A set of mailbox registers can be allocated to each thread of a plurality of threads that can be executed in the microprocessor. A mailbox register in the set of mailbox registers comprises an identifier of a next thread of the plurality of threads to which an active thread switches based on a thread switch condition further indicated in the mailbox register. The auxiliary registers in the microprocessor can be used to configure a number of threads for simultaneous execution in the microprocessor, a priority for thread switching, and to store a program counter of each thread and states of registers of each thread.