Embodiments of the present invention include systems and methods for dynamically adjusting instrumentation scope of a profiler gent. The method for dynamically adjusting an instrumentation scope of a profiler agent includes: supplying an initial instrumentation scope profile (ISP) that defines an instrumentation scope of a profiler agent to the profiler agent; receiving performance data of a call tree from the profiler agent based on the initial ISP; adjusting the instrumentation scope; updating the initial ISP based on the adjusted instrumentation scope; and supplying the updated ISP to the profiler agent. Adjusting the instrumentation scope includes at least one of expanding a child node of the call tree and excluding a child node of the call tree from the instrumentation scope.