A multiphase serialization system for a voltage-mode transmitter includes a N-to-one stage driven by a N-phase input clock, a phase alignment unit driven by the N-phase input clock being operated to generated interpolated sampling clock signals by adjusting a plurality of reference clock signals provided to the phase alignment unit based on the N-phase input clock, and a preceding multiplexing stage driven by the interpolated sampling clock signals configured to receive incoming data streams and to output phase aligned data streams to the N-to-one stage.