The present invention relates to an image sensor communication (ISC) system and method for enabling communication between an LED and a rolling shutter camera using a rolling shutter modulation method. The image sensor communication system according to an embodiment of the present invention comprises: a coding unit for coding transmission data to be transmitted; an LED which is turned on/off according to the transmission data coded in the coding unit; a rolling shutter camera for continuously photographing, at each of a plurality of rows in a rolling shutter manner, on/off images according to the on/off of the LED; an image processing unit for generating brightness signals according to brightness values of the on/off images of the LED photographed at each of the plurality of rows by the rolling shutter camera; and a data extraction unit for extracting the transmission data from the brightness signals of the on/off images of the LED generated by the image processing unit.