Methods and systems for improving performance of an HTTP cache are provided. According to one embodiment, an HTTP request is received by an ADC for a resource associated with a server on behalf of which the ADC is performing load balancing. The ADC determines based on a local HTTP cache whether it can service the request. The request is parsed to identify a header. The existence or non-existence of locally cached content matching the request is identified by comparing portions of the identified header with corresponding portions of header information of cached content based on a vary rule defining when two headers are meaningfully different. Therefore, the identified header need not exactly match an entirety of the cached information for a cache hit to be found. Responsive to a cache hit, the ADC responds to the request with an HTTP response containing the identified locally cached content.