Invention Grant
- Patent Title: In vivo positron emission tomography-based perfusion/blood pool imaging using labeled erythrocytes
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Application No.: US15780568Application Date: 2017-01-11
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Publication No.: US10561379B2Publication Date: 2020-02-18
- Inventor: Jung Wook Choi
- Applicant: H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.
- Applicant Address: US FL Tampa
- Assignee: H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.
- Current Assignee: H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.
- Current Assignee Address: US FL Tampa
- Agency: Saliwanchik, Lloyd & Eisenschenk
- International Application: PCT/US2017/013063 WO 20170111
- International Announcement: WO2017/123666 WO 20170720
- Main IPC: A61B6/03
- IPC: A61B6/03 ; A61K35/18 ; A61K51/12 ; A61K51/04 ; A61B6/00
Abstract:
The present invention concerns a positron emission tomography (PET) contrast agent or imaging tracer comprising a red blood cell (RBC) internally labeled with 2-deoxy-2-(18F)fluoro-D-glucose (FDG); a method of preparing RBCs of a human or non-human animal for PET, comprising labeling RBCs in vitro with FDG to produce FDG-labeled RBCs; a method for in vivo imaging of RBCs using PET, comprising: introducing RBCs internally labeled with FDG (FDG-RBCs) into the circulatory system of a human or non-human animal subject in vivo; and PET imaging the introduced FDG-RBCs in the subject; a composition useful for labeling RBCs, and a kit for labeling RBCs.
Public/Granted literature
- US20180344264A1 IN VIVO POSITRON EMISSION TOMOGRAPHY-BASED PERFUSION/BLOOD POOL IMAGING USING LABELED ERYTHROCYTES Public/Granted day:2018-12-06
Information query
