- Patent Title: N-(substituted-phenyl)-sulfonamide derivatives as kinase inhibitors
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Application No.: US16312061Application Date: 2017-06-19
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Publication No.: US10561660B2Publication Date: 2020-02-18
- Inventor: Simona Bindi , Davide Carenzi , Ilaria Motto , Maurizio Pulici
- Applicant: Nerviano Medical Sciences S.R.L.
- Agency: Silvia Salvadori, P.C.
- Agent Silvia Salvadori
- Priority: EP16175386 20160621
- International Application: PCT/EP2017/064904 WO 20170619
- International Announcement: WO2017/220477 WO 20171228
- Main IPC: C07D487/04
- IPC: C07D487/04 ; A61K31/519 ; C07D513/04 ; A61P37/00 ; A61P25/28 ; A61P35/00 ; A61K31/4355 ; A61K31/4365 ; C07D491/048 ; C07D495/04
Abstract:
The invention relates to N-(substituted-phenyl)-sulfonamide compounds, which are extremely useful as inhibitors of protein kinases (e.g. PERK kinase) and accordingly can be used for the treatment of cell proliferative disorders, such as cancer, or diseases associated with activated unfolded protein response pathways, such as Alzheimer's disease. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing pharmaceutical compositions comprising these compounds.
Public/Granted literature
- US20190201406A1 N-(SUBSTITUTED-PHENYL)-SULFONAMIDE DERIVATIVES AS KINASE INHIBITORS Public/Granted day:2019-07-04
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