Invention Grant
- Patent Title: Method for significantly increasing lentiviral production
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Application No.: US16093959Application Date: 2017-05-31
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Publication No.: US10562939B2Publication Date: 2020-02-18
- Inventor: Stephen P. Goff , Yiping Zhu , Liang Tong , Shukun Luo
- Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
- Applicant Address: US NY New York
- Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
- Current Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
- Current Assignee Address: US NY New York
- Agency: Leason Ellis LLP
- International Application: PCT/US2017/035279 WO 20170531
- International Announcement: WO2017/210337 WO 20171207
- Main IPC: A61K38/00
- IPC: A61K38/00 ; A61K39/00 ; C07K14/005 ; C07K14/02 ; C07K14/05 ; C12N15/113 ; C12N7/00

Abstract:
Increased viral particle maturation and production can be achieved in various methods for producing viral particles from viral proteins, in general, by inhibiting or preventing Heme Oxygenase 2 (HO-2) from binding to the group-specific antigen (Gag) of the viral proteins, thus allowing delivery of the viral proteins to plasma membranes where they can replicate and mature without interference from HO-2. The increase in viral particle maturation and production can also be achieved by minimizing or eliminating the presence of HO-2 to thus reduce or prevent binding of HO-2 to the group-specific antigen (Gag) of the viral proteins. The invention is particularly applicable to the production of lentiviruses from viral proteins wherein the Matrix domain (MA) of the Gag is myristoylated.
Public/Granted literature
- US20190153038A1 METHOD FOR SIGNIFICANTLY INCREASING LENTIVIRAL PRODUCTION Public/Granted day:2019-05-23
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