Invention Grant
- Patent Title: Computationally optimized broadly reactive antigens for H1N1 influenza
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Application No.: US16119501Application Date: 2018-08-31
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Publication No.: US10562940B2Publication Date: 2020-02-18
- Inventor: Ted M. Ross , Corey J. Crevar
- Applicant: University of Pittsburgh—Of the Commonwealth System of Higher Education
- Applicant Address: US PA Pittsburgh
- Assignee: University of Pittsburgh— Of the Commonwealth System of Higher Education
- Current Assignee: University of Pittsburgh— Of the Commonwealth System of Higher Education
- Current Assignee Address: US PA Pittsburgh
- Agency: Klarquist Sparkman, LLP
- Main IPC: C07K14/005
- IPC: C07K14/005 ; A61K39/12 ; A61K39/145 ; C12N7/00 ; A61K39/00
Abstract:
Described herein is the generation of optimized H1N1 influenza HA polypeptides for eliciting a broadly reactive immune response to H1N1 influenza virus isolates. The optimized HA polypeptides were developed through a series of HA protein alignments, and subsequent generation of consensus sequences, based on selected H1N1 viruses isolated from 1918-2011. Provided herein are optimized H1N1 HA polypeptides, and compositions, fusion proteins and VLPs comprising the HA polypeptides. Further provided are codon-optimized nucleic acid sequences encoding the HA polypeptides. Methods of eliciting an immune response against influenza virus in a subject are also provided by the present disclosure.
Public/Granted literature
- US20180371025A1 COMPUTATIONALLY OPTIMIZED BROADLY REACTIVE ANTIGENS FOR H1N1 INFLUENZA Public/Granted day:2018-12-27
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