Invention Grant
- Patent Title: Anti-CD276 chimeric antigen receptors
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Application No.: US15757728Application Date: 2016-09-09
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Publication No.: US10562952B2Publication Date: 2020-02-18
- Inventor: Crystal L. Mackall , Yongzhi Karen Cui
- Applicant: The United States of America, as represented by the Secretary, Department of Health and Human Services
- Applicant Address: US MD Bethesda
- Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
- Current Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
- Current Assignee Address: US MD Bethesda
- Agency: Leydig, Voit & Mayer, Ltd.
- International Application: PCT/US2016/050887 WO 20160909
- International Announcement: WO2017/044699 WO 20170316
- Main IPC: C07K14/705
- IPC: C07K14/705 ; A61P35/00 ; G01N33/574
Abstract:
Chimeric antigen receptors (CARs) that specifically bind to and immunologically recognize CD276 are disclosed. Related nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions relating to the polypeptides and proteins are also disclosed. Methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal are also disclosed.
Public/Granted literature
- US20180346544A1 ANTI-CD276 CHIMERIC ANTIGEN RECEPTORS Public/Granted day:2018-12-06
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