Invention Grant
- Patent Title: Methods for producing Fabs and bi-specific antibodies
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Application No.: US16298113Application Date: 2019-03-11
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Publication No.: US10562982B2Publication Date: 2020-02-18
- Inventor: Stephen J Demarest , Xiufeng Wu , Raheleh Toughiri , Brian Arthur Kuhlman , Steven Morgan Lewis
- Applicant: Eli Lilly and Company , The University of North Carolina at Chapel Hill
- Applicant Address: US IN Indianapolis US NC Chapel Hill
- Assignee: Eli Lilly and Company,The University of North Carolina at Chapel Hill
- Current Assignee: Eli Lilly and Company,The University of North Carolina at Chapel Hill
- Current Assignee Address: US IN Indianapolis US NC Chapel Hill
- Agent Xiaoguang Gao
- Main IPC: C07K16/46
- IPC: C07K16/46 ; C07K16/32 ; C07K16/00 ; C07K16/28
Abstract:
The present invention provides methods for producing Fabs and bi-specific antibodies comprising designed residues in the interfaces of the heavy chain-light chain variable (VH/VL) domain and the heavy chain-light chain constant (CH1/CL) domain, Fabs and bi-specific antibodies produced according to said processes and host cells encoding the same.
Public/Granted literature
- US20190211115A1 METHODS FOR PRODUCING FABS AND BI-SPECIFIC ANTIBODIES Public/Granted day:2019-07-11
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