Invention Grant
- Patent Title: Populations of mesenchymal stem cells that secrete neurotrophic factors
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Application No.: US15113105Application Date: 2015-02-11
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Publication No.: US10564149B2Publication Date: 2020-02-18
- Inventor: Yael Gothelf , Yosef Levy
- Applicant: BrainStorm Cell Therapeutics Ltd.
- Applicant Address: IL Petach-Tikva
- Assignee: BrainStorm Cell Therapeutics Ltd.
- Current Assignee: BrainStorm Cell Therapeutics Ltd.
- Current Assignee Address: IL Petach-Tikva
- International Application: PCT/IL2015/050159 WO 20150211
- International Announcement: WO2015/121859 WO 20150820
- Main IPC: A61K35/28
- IPC: A61K35/28 ; G01N33/50 ; C12N5/0775

Abstract:
A method of qualifying whether a cell population is a suitable therapeutic is disclosed. The method comprises: (a) incubating a population of undifferentiated mesenchymal stem cells (MSCs) in a differentiating medium comprising basic fibroblast growth factor (bFGF), platelet derived growth factor (PDGF), heregulin and cAMP for at least two days to obtain a population of differentiated MSCs; and (b) analyzing the expression of CD49 a in the differentiated MSC population, wherein an amount of CD49 a above a predetermined level indicative of the cell population being suitable as a therapeutic.
Public/Granted literature
- US20160334392A1 METHOD OF QUALIFYING CELLS Public/Granted day:2016-11-17
Information query
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