Invention Grant
- Patent Title: Fluorescent probe, singlet oxygen detection agent, and singlet oxygen detection method
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Application No.: US15320162Application Date: 2015-06-17
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Publication No.: US10564164B2Publication Date: 2020-02-18
- Inventor: Tetsuro Majima , Sooyeon Kim , Takashi Tachikawa , Mamoru Fujitsuka
- Applicant: Osaka University
- Applicant Address: JP Osaka
- Assignee: Osaka University
- Current Assignee: Osaka University
- Current Assignee Address: JP Osaka
- Agency: Calderone Bullock, LLC
- Agent Lynda L. Calderone
- Priority: JP2014-124543 20140617
- International Application: PCT/JP2015/067522 WO 20150617
- International Announcement: WO2015/194606 WO 20151223
- Main IPC: C07F7/10
- IPC: C07F7/10 ; G01N33/58

Abstract:
An object of the present invention is to provide a fluorescent probe that easily penetrates a cell and is capable of selectively and efficiently detecting singlet oxygen generated in the cell, a singlet oxygen detection agent containing the fluorescent probe, and a singlet oxygen detection method using the fluorescent probe. The fluorescent probe for detecting singlet oxygen comprises a compound having a silicon-rhodamine skeleton and a skeleton that increases the fluorescence of the fluorescent probe after trapping singlet oxygen to be greater than the fluorescence before trapping singlet oxygen, or a salt, hydrate, or solvate thereof.
Public/Granted literature
- US20170363636A1 Fluorescent Probe, Singlet Oxygen Detection Agent, and Singlet Oxygen Detection Method Public/Granted day:2017-12-21
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