Display systems and related methods involving bus lines with low capacitance cross-over structures are provided. A representative display system includes: a first structure comprising: a plurality of scan lines extending in a first direction; and a plurality of data lines extending in a second direction and crossing over the scan lines at respective cross-over locations, each of the plurality of data lines having a pair of side walls spaced apart from each other at each of the cross-over locations, with each of the side walls exhibiting a height higher than portions of the data lines not located at the cross-over locations.