Mapping of semantics in healthcare may involve accessing first transaction data in a first database, the first transaction data corresponding to a collection of a first number of fields defined for a condition using a first semantic system to store information and calculating a first distribution of information in the first transaction data. Mapping may also involve accessing second transaction data in a second database, the second transaction data corresponding to a second semantic system different than the first semantic system and the second database comprising a second number of fields using the second semantic system to store information, and calculating a second distribution of information in the second transaction data. The distributions may then be compared and a map relating the semantic systems may be generated and used to communicate between the first and second semantic systems.