Methods, apparatuses, and systems of route planning for package pickup and delivery includes: receiving predetermined locations in a geographic region and data representing a predetermined route connecting the predetermined locations; determining unit areas in the geographic region based on sequential nearness of the predetermined locations along the predetermined route, the unit areas including a first unit area and a second unit area, and the unit areas being configured such that all locations in the first unit area are to be visited before visiting locations of the second unit area; generating delivery patterns for determining a route connecting at least one of the unit areas, each delivery pattern including at least one of the unit areas associated with a visiting sequence; when receiving task data including target locations to visit, determining a target route using the delivery patterns and the target data; and sending the target route to a mobile apparatus.