Systems and techniques are disclosed for determination of lesions identified in medical images of differing perspectives. One of the methods includes obtaining images of a breast of a patient, each image being from a perspective, wherein the images include at least a first image and a second image. A skin contour line representing an obliquity of a chest wall of the patient is determined. A posterior nipple line extending from a nipple included in the first image is determined that perpendicularly intersects with the skin contour line. An interactive user interface is presented that includes the posterior nipple line on the first image. Compatibility information for lesions indicated in each of the first and second image is determined, the information indicating whether a first lesion in the first image is a same lesion in the breast as a second lesion in the second image.