A splicing screen, a method and a device for driving the splicing screen and a display apparatus are provided. The splicing screen includes at least one main display region configured to display a first portion of a display image, and a frame display region at edges of the main display region and configured to display a second portion of the display image other than the first portion. The method includes calculating a division manner for a display image; and displaying different portions of the image correspondingly on the main display region and the frame display region according to the division manner. The device for driving the splicing screen includes an image capture module and an image division display module.