This disclosure relates generally to cloud radio access network (C-RAN), and more particularly to X2-messaging in the C-RAN. The method may include receiving, by a control unit in the CRAN, in the C-RAN, a request from a first virtual eNodeB (eNB) associated with a source eNodeB (eNB) to establish a X2 interface with each virtual eNB associated with a set of neighbor eNBs. A second virtual eNB associated with a target eNB may be selected from the virtual eNBs associated with the set of neighbor eNBs. A check may be made to determine whether the first virtual eNB and the second virtual eNB associated with the target eNB are co-located on same datacenter in the C-RAN. At least one X2 message may be transmitted between the first virtual eNB and the second virtual eNB that are co-located on the datacenter based on eNB information accessed from a shared storage.