An aeroponic growing column system comprises a plurality of vertical growth columns, a plurality of growing receptacles, and a reservoir base having a first plurality of column receiving holes. The vertical growth columns have an elongated body with a fluid receiving end at a top end, an opposite fluid draining end at a base end, an interior receiving space extending between the fluid receiving end and the fluid draining end, and a plurality of growing receptacle receiving openings positioned on the body. The growing receptacles are positioned in the growing receptacle receiving openings. The fluid draining end of each vertical growth column is removably positioned in a different one of the first plurality of column receiving holes and supported by the reservoir base.