Invention Grant
- Patent Title: Non-human mammals for the production of chimeric antibodies
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Application No.: US15095917Application Date: 2016-04-11
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Publication No.: US10575504B2Publication Date: 2020-03-03
- Inventor: Larry Green , Hiroaki Shizuya
- Applicant: ABLEXIS, LLC
- Applicant Address: US CA San Diego
- Assignee: ABLEXIS, LLC
- Current Assignee: ABLEXIS, LLC
- Current Assignee Address: US CA San Diego
- Agency: Haley Guiliano LLP
- Agent James F. Haley, Jr.; Brian M. Gummow
- Main IPC: C07H21/02
- IPC: C07H21/02 ; C12N15/63 ; A01K67/00 ; A01K67/027 ; C12N15/85 ; C07K16/00 ; C07K16/28 ; C07K16/46
Abstract:
The invention provides knock-in non-human cells and mammals having a genome encoding chimeric antibodies and methods of producing knock-in cells and mammals. Certain aspects of the invention include chimeric antibodies, humanized antibodies, pharmaceutical compositions and kits. Certain aspects of the invention also relate to diagnostic and treatment methods using the antibodies of the invention.
Public/Granted literature
- US20160219850A1 NON-HUMAN MAMMALS FOR THE PRODUCTION OF CHIMERIC ANTIBODIES Public/Granted day:2016-08-04
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