The present invention relates to a coenzyme Q10 solubilizing composition and a method for preparing the same. In the coenzyme Q10 solubilizing composition and the method for preparing the same according to the present invention, coenzyme Q10, which is a non-soluble drug, is encapsulated by a micelle containing glycyrrhizic acid or a salt of glycyrrhizic acid, bile acid, and unsaturated fatty acid, thereby improving encapsulation efficiency and improving the solubility of coenzyme Q10 in water. In addition, the mass-production of the composition can be easily achieved through sonication or a microfluidizer, the particle size of the composition encapsulating coenzyme Q10 can be controlled, and the natural substance-based formulation without using ethanol and an organic solvent are possible, so that it is expected that the composition of the present invention can be favorably utilized as a composition for pharmaceuticals, foods, and cosmetics, the composition having ensured stability and almost no toxicity.