Invention Grant
- Patent Title: Nitrated-fatty acids modulation of type II diabetes
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Application No.: US16280704Application Date: 2019-02-20
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Publication No.: US10576051B2Publication Date: 2020-03-03
- Inventor: Bruce A. Freeman , Francisco J. Schopfer
- Applicant: University of Pittsburgh—Of the Commonwealth System of Higher Education
- Applicant Address: US PA Pittsburgh
- Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
- Current Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
- Current Assignee Address: US PA Pittsburgh
- Agency: Klarquist Sparkman, LLP
- Main IPC: A61K31/202
- IPC: A61K31/202 ; A61K31/201 ; A61K31/20 ; A61K45/06
Abstract:
Nitro oleic acid and related metabolites are agonists of PPAR-γ. Surprisingly, nitro oleic acid is a more potent agonist of PPAR-γ, relative to nitro linoleic acid. Thus, nitro oleic acid and its metabolites, as well as their pharmaceutically acceptable salts and prodrug forms, are candidate therapeutics for the treatment of type-2 diabetes, which results from insulin resistance accompanying the improper functioning of PPAR-γ.
Public/Granted literature
- US20190274987A1 NITRATED-FATTY ACIDS MODULATION OF TYPE II DIABETES Public/Granted day:2019-09-12
Information query
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