Invention Grant
![Spiro[3H-indole-3,2′-pyrrolidin]-2(1H)-one compounds and derivatives as MDM2-P53 inhibitors](/docs/US/2020-03-03/US10576064B2/abs.jpg.600x600.jpg)
- Patent Title: Spiro[3H-indole-3,2′-pyrrolidin]-2(1H)-one compounds and derivatives as MDM2-P53 inhibitors
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Application No.: US14790032Application Date: 2015-07-02
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Publication No.: US10576064B2Publication Date: 2020-03-03
- Inventor: Harald Weinstabl , Andreas Gollner , Juergen Ramharter , Tobias Wunberg
- Applicant: Boehringer Ingelheim International GmbH
- Applicant Address: DE Ingelheim am Rhein
- Assignee: Boehringer Ingelheim International GmbH
- Current Assignee: Boehringer Ingelheim International GmbH
- Current Assignee Address: DE Ingelheim am Rhein
- Agent Philip I. Datlow
- Priority: EP14175620 20140703
- Main IPC: A61K31/437
- IPC: A61K31/437 ; A61K45/06 ; C07D471/20 ; C07D471/22 ; C07D491/20 ; A61K31/407 ; C07D487/20 ; A61K31/635 ; A61K31/427
![Spiro[3H-indole-3,2′-pyrrolidin]-2(1H)-one compounds and derivatives as MDM2-P53 inhibitors](/abs-image/US/2020/03/03/US10576064B2/abs.jpg.150x150.jpg)
Abstract:
The present invention relates to compounds of formula (I) wherein the groups R1 to R3, R7, U, V, W, X, Y, n and q are as defined herein, their use as inhibitors of MDM2-p53 interaction, pharmaceutical compositions which contain compounds of this kind, their use as medicaments, especially as agents for treatment and/or prevention of oncological diseases and synthetic intermediates.
Public/Granted literature
- US20160000764A1 NEW SPIRO[3H-INDOLE-3,2'-PYRROLIDIN]-2(1H)-ONE COMPOUNDS AND DERIVATIVES AS MDM2-P53 INHIBITORS Public/Granted day:2016-01-07
Information query
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