Invention Grant
- Patent Title: Oncolytic HSV vector
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Application No.: US16191141Application Date: 2018-11-14
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Publication No.: US10576115B2Publication Date: 2020-03-03
- Inventor: Hiroaki Uchida , Justus B. Cohen , Joseph C. Glorioso, III , Paola Grandi
- Applicant: University of Pittsburgh—Of the Commonwealth System of Higher Education
- Applicant Address: US PA Pittsburgh
- Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
- Current Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
- Current Assignee Address: US PA Pittsburgh
- Agency: Leydig, Voit & Mayer, Ltd.
- Main IPC: C12N15/00
- IPC: C12N15/00 ; A61K35/763 ; C12N7/00 ; C07K14/005
Abstract:
The present invention provides a recombinant herpes simplex virus (HSV), comprising (a) a mutation of the glycoprotein B (gB) at position 285 or 549, (b) a plurality of copies of one or more microRNA target sequences inserted into a locus of an HSV gene required for HSV replication, wherein said target sequence is the reverse complement of microRNA miR-124 and wherein said target sequence is present in the ICP4 gene, and (c) a transgene encoding a matrix metalloproteinase. The present invention also provides a method of killing a cancerous cell using a recombinant HSV according to the invention and a pharmaceutical composition comprising a pharmaceutically acceptable carrier and a recombinant HSV according to the invention.
Public/Granted literature
- US20190262410A1 ONCOLYTIC HSV VECTOR Public/Granted day:2019-08-29
Information query
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