Invention Grant
- Patent Title: Aminonapthoquinone compounds and pharmaceutical composition for blocking ubiquitination-proteasome system in diseases
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Application No.: US15746964Application Date: 2015-07-23
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Publication No.: US10577328B2Publication Date: 2020-03-03
- Inventor: Yun Yen , Jing-ping Liou , Shiow-lin Pan
- Applicant: TAIPEI MEDICAL UNIVERSITY
- Applicant Address: TW Taipei
- Assignee: Taipei Medical University
- Current Assignee: Taipei Medical University
- Current Assignee Address: TW Taipei
- Agency: Duane Morris LLP
- International Application: PCT/US2015/041767 WO 20150723
- International Announcement: WO2017/014788 WO 20170126
- Main IPC: C07D213/75
- IPC: C07D213/75 ; C07D213/74 ; A61P37/00 ; A61P25/28 ; A61P35/02 ; A61P3/10 ; C07D209/04 ; C07D215/40 ; C07D215/42 ; C07D231/38 ; C07D235/30 ; C07D239/42 ; C07D241/04 ; C07D241/20 ; C07D277/42 ; C07D471/04 ; C07D487/04 ; A61K31/337 ; A61K31/475 ; A61K31/506 ; A61K31/593 ; A61K31/704 ; A61K33/24
Abstract:
The invention relates to a compound of formula (I) with low cytotoxicity for blocking the ubiquitination-proteasome system in diseases. Accordingly, these compounds can be used in treatment of disorders including, but not limited to, multiple myeloma, cancers, neurodegenerative diseases, inflammatory disorders, autoimmune disorders and metabolic disorders.
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