Invention Grant
- Patent Title: Fused-bicyclic aryl quinolinone derivatives as mutant-isocitrate dehydrogenase inhibitors
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Application No.: US16351457Application Date: 2019-03-12
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Publication No.: US10577329B2Publication Date: 2020-03-03
- Inventor: Jian Lin , Anna Ericsson , Ann-Marie Campbell , Gary Gustafson , Zhongguo Wang , R. Bruce Diebold , Susan Ashwell , David R. Lancia, Jr. , Justin Andrew Caravella , Wei Lu
- Applicant: FORMA Therapeutics, Inc.
- Applicant Address: US MA Watertown
- Assignee: Forma Therapeutics, Inc.
- Current Assignee: Forma Therapeutics, Inc.
- Current Assignee Address: US MA Watertown
- Agency: Choate, Hall & Stewart LLP
- Agent John P. Rearick; Erica M. D'Amato
- Main IPC: C07D215/227
- IPC: C07D215/227 ; C07D403/12 ; C07D401/12 ; C07D405/12 ; C07D413/12 ; C07D417/12 ; C07D487/04 ; C07D471/04 ; C07D498/04 ; C07D401/14 ; C07D519/00 ; A61P35/00
Abstract:
The invention relates to inhibitors of mutant isocitrate dehydrogenase (mt-IDH) proteins with neomorphic activity useful in the treatment of cell-proliferation disorders and cancers, having the Formula: where A, B, U, V, Z, W1, W2, W3, and R1-R6 are described herein.
Public/Granted literature
- US20190202790A1 FUSED-BICYCLIC ARYL QUINOLINONE DERIVATIVES AS MUTANT-ISOCITRATE DEHYDROGENASE INHIBITORS Public/Granted day:2019-07-04
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