Invention Grant
- Patent Title: Small molecule histone methyltransferase SUV39H1 inhibitor and uses thereof
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Application No.: US16134306Application Date: 2018-09-18
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Publication No.: US10577371B2Publication Date: 2020-03-03
- Inventor: Chunwan Lu , Iryna Lebedyeva , Kebin Liu
- Applicant: Augusta University Research Institute, Inc. , Department of Veterans Affairs
- Applicant Address: US GA Augusta US DC Washington
- Assignee: Augusta University Research Institute, Inc.,Department of Veterans Affairs
- Current Assignee: Augusta University Research Institute, Inc.,Department of Veterans Affairs
- Current Assignee Address: US GA Augusta US DC Washington
- Agency: Smith, Gambrell & Russell, LLP
- Main IPC: C07D487/04
- IPC: C07D487/04 ; A61K45/06 ; A61P35/00 ; A61K39/395 ; A61K31/407 ; C07K16/28 ; A61K39/00
Abstract:
Compositions for the inhibition of SUV39H1 methyltransferase activity and methods of use thereof are provided. The disclosed compositions may be used for treating certain types of cancer, inducing apoptosis in a cancer cell, increasing cell sensitivity to FasL-induced apoptosis, and overcoming cancer cell resistance to apoptosis and/or certain types of cancer immunotherapy.
Public/Granted literature
- US20190084987A1 Small Molecule Histone Methyltransferase SUV39H1 Inhibitor and Uses Thereof Public/Granted day:2019-03-21
Information query
