Invention Grant
- Patent Title: Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydrocodone, prodrugs, methods of making and use thereof
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Application No.: US15843875Application Date: 2017-12-15
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Publication No.: US10577376B2Publication Date: 2020-03-03
- Inventor: Travis Mickle , Sven Guenther , Christal Mickle , Guochen Chi , Jaroslaw Kanski , Andrea K. Martin , Bindu Bera
- Applicant: KemPharm, Inc.
- Applicant Address: US FL Celebration
- Assignee: KemPharm, Inc.
- Current Assignee: KemPharm, Inc.
- Current Assignee Address: US FL Celebration
- Agency: McAndrews, Held & Malloy, Ltd.
- Main IPC: A61K31/485
- IPC: A61K31/485 ; A61K31/167 ; A61K47/55 ; C07D491/08 ; C07D489/04 ; C07D489/02 ; A61K47/54 ; A61K9/20 ; A61P25/30 ; A61K47/48 ; A61K45/06 ; A61K9/00
Abstract:
The presently described technology provides methods of treating a patient having moderate to severe pain, narcotic or opioid abuse or narcotic or opioid withdrawal. The presently described methods are carried out by comprising administering to the patient a pharmaceutically effective amount of a composition comprising acetaminophen and benzoate-hydrocodone hydrochloride. The composition has reduced side effects when compared with unconjugated hydrocodone.
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