Invention Grant
- Patent Title: Macrocyclic inhibitors of myeloperoxidase
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Application No.: US16099010Application Date: 2017-06-26
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Publication No.: US10577383B2Publication Date: 2020-03-03
- Inventor: Joanne M. Smallheer , Ellen K. Kick , Meriah Neissel Valente , Carol Hui Hu , Oz Scott Halpern , Sutjano Jusuf
- Applicant: BRISTOL-MYERS SQUIBB COMPANY
- Applicant Address: US NJ Princeton
- Assignee: Bristol-Myers Squibb Company
- Current Assignee: Bristol-Myers Squibb Company
- Current Assignee Address: US NJ Princeton
- Agent Elliott Korsen
- International Application: PCT/US2017/039228 WO 20170626
- International Announcement: WO2018/005336 WO 20180104
- Main IPC: C07D519/00
- IPC: C07D519/00 ; A61P9/10
Abstract:
The present invention provides compounds of Formula (I): wherein the substituents are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are myeloperoxidase (MPO) inhibitors and/or eosinophil peroxidase (EPX) inhibitors, and may be useful for for the treatment and/or prophylaxis of atherosclerosis, heart failure, chronic obstructive pulmonary disease (COPD), and related diseases.
Public/Granted literature
- US20190177340A1 MACROCYCLIC INHIBITORS OF MYELOPEROXIDASE Public/Granted day:2019-06-13
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