Invention Grant
- Patent Title: Oligonucleotide conjugation process
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Application No.: US15771206Application Date: 2016-09-29
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Publication No.: US10577388B2Publication Date: 2020-03-03
- Inventor: Dennis Jul Hansen , Christoph Rosenbohm , Michael Meldgaard
- Applicant: Roche Innovation Center Copenhagen A/S
- Applicant Address: CH Basel
- Assignee: Roche Innovation Center Copenhagen A/S
- Current Assignee: Roche Innovation Center Copenhagen A/S
- Current Assignee Address: CH Basel
- Agency: Fish & Richardson P.C.
- Priority: EP15188120 20151002
- International Application: PCT/EP2016/073224 WO 20160929
- International Announcement: WO2017/055423 WO 20170406
- Main IPC: C07H21/00
- IPC: C07H21/00 ; C07H1/00 ; C07H19/06 ; C07H19/16 ; A61K47/55 ; A61K47/54 ; C07H21/02 ; C07H21/04
Abstract:
The present invention relates to the field of oligonucleotide conjugates and to methods of synthesis thereof. In the present method a low-water content solvent environment allows a more efficient conjugation, reducing the amount of conjugate moiety needed and increasing the conjugation reaction speed.
Public/Granted literature
- US20180305392A1 Oligonucleotide Conjugation Process Public/Granted day:2018-10-25
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