Invention Grant
- Patent Title: Use of ICOS-based CARS to enhance antitumor activity and CAR persistence
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Application No.: US15637734Application Date: 2017-06-29
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Publication No.: US10577407B2Publication Date: 2020-03-03
- Inventor: Carl H. June , Sonia Guedan Carrio , Yangbing Zhao , John Scholler
- Applicant: The Trustees of the University of Pennsylvania
- Applicant Address: US PA Philadelphia
- Assignee: The Trustees of the University of Pennsylvania
- Current Assignee: The Trustees of the University of Pennsylvania
- Current Assignee Address: US PA Philadelphia
- Agency: Saul Ewing Arnstein & Lehr LLP
- Agent Kathryn Doyle
- Main IPC: A01N63/00
- IPC: A01N63/00 ; A61K48/00 ; C07K14/705 ; C07K14/725 ; A61K35/12
Abstract:
The present invention provides compositions and methods for treating cancer in a human. The invention includes administering a genetically modified Th17 cell to express a CAR having an antigen binding domain, a transmembrane domain, and an ICOS intracellular signaling domain.
Public/Granted literature
- US20170362295A1 USE OF ICOS-BASED CARS TO ENHANCE ANTITUMOR ACTIVITY AND CAR PERSISTENCE Public/Granted day:2017-12-21
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